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The tmRNA Website

The tmRNA Website

The tmRNA Website

Page Contact
Kelly Williams

(925) 294-4730

Corey Hudson

(925) 294-1575

Related Links
Islander (genomic islands)
Sandia Bioinformatics

Cite website

The tmRNA Website

tmRNA is a bacterial RNA molecule with dual tRNA-like and mRNA-like properties. It forms an RNA-protein complex with ribosomal protein S1, elongation factor Tu, and the dedicated protein SmpB.

tmRNA at Wikipedia
This complex enters ribosomes that have stalled during protein elongation and promotes: i) rescue of the stalled ribosome, ii) degradation of the problematic mRNA, and iii) extension of the unfinished polypeptide, first with the alanine charging tmRNA and then with the proteolysis-inducing tag encoded by tmRNA.

Most bacteria encode a standard one-piece tmRNA. In other bacterial species, a permuted tmRNA gene produces a two-piece tmRNA in which two separate RNA chains are joined by base-pairing.

Molecule of the Month
Jan 2013 at PDB
The current (22-Oct-2013) database contains 1631 unique sequences and links these to 12509 instances in GenBank/EMBL-EBI/DDBJ (INSDC) entries that comprise 7590 taxa.

Citation: Hudson CM and Williams KP (2015) The tmRNA Website. Nucleic Acids Res. 43: D138-140.

Taxonomic browsing by Krona: Ondov BD, Bergman NH, Phillippy AM (2011) Interactive metagenomic visualization in a Web browser. BMC bioinformatics. 12:385

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